Expression of EMB in cancer - Summary - The Human Protein Atlas

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EMB

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	EMB
Gene description	Embigin
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (THP-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	EMB (HGNC Symbol)
Synonyms	MGC71745
Description	Embigin (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]
Chromosome	5
Cytoband	q11.1
Chromosome location (bp)	50396192 - 50443248
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170571 (version 83.38)
Entrez gene	133418
UniProt	Q6PCB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PCB8
Antibodypedia	EMB antibodies

PROTEIN BROWSER

EMB-001	EMB-003	EMB-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMB-001 ENSP00000302289 ENST00000303221	Q6PCB8 [Direct mapping] Embigin Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0030054 [cell junction] GO:0035879 [plasma membrane lactate transport] GO:0045202 [synapse] Show all	327 aa 36.9 kDa	Yes	1
EMB-003 ENSP00000426404 ENST00000514111	Q6PCB8 [Direct mapping] Embigin Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0030054 [cell junction] GO:0035879 [plasma membrane lactate transport] GO:0045202 [synapse] Show all	277 aa 31.6 kDa	No	1
EMB-005 ENSP00000425215 ENST00000508934	D6RDX7 [Direct mapping] Embigin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	273 aa 30.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.