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STAT2

GENERAL INFORMATION

Gene name

 STAT2

Gene description

 Signal transducer and activator of transcription 2, 113kDa

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA018888 , CAB003858
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018888
CAB003858

GENE INFORMATION

Gene name

 STAT2 (HGNC Symbol)

Synonyms

 STAT113

Description

 Signal transducer and activator of transcription 2, 113kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56341597 - 56360155

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170581 (version 83.38)

Entrez gene

 6773

UniProt

 P52630 (UniProt - Evidence at protein level)

neXtProt

 NX_P52630

Antibodypedia

 STAT2 antibodies

PROTEIN BROWSER
STAT2-001
STAT2-002
STAT2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAT2-001
ENSP00000450751
ENST00000557235
P52630 [Direct mapping]
Signal transducer and activator of transcription 2
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 847 aa
97.5 kDa 		No 0
STAT2-002
ENSP00000315768
ENST00000314128
P52630 [Direct mapping]
Signal transducer and activator of transcription 2
R9QE65 [Target identity:100%; Query identity:100%]
Signal transducer and activator of transcription
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 851 aa
97.9 kDa 		No 0
STAT2-004
ENSP00000387354
ENST00000418572
B4DLC8 [Direct mapping]
Signal transducer and activator of transcription 2; cDNA FLJ59331, highly similar to Signal transducer and activator of transcription 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 460 aa
53 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.