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FOXA3

GENERAL INFORMATION

Gene name

 FOXA3

Gene description

 Forkhead box A3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CACO-2, HDLM-2, Hep G2, K-562, NTERA-2)
HPA (normal tissue):Group enriched (colon, duodenum, liver, pancreas, rectum, small intestine, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB015154
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB015154

GENE INFORMATION

Gene name

 FOXA3 (HGNC Symbol)

Synonyms

 HNF3G

Description

 Forkhead box A3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45863989 - 45873797

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170608 (version 83.38)

Entrez gene

 3171

UniProt

 P55318 (UniProt - Evidence at protein level)

neXtProt

 NX_P55318

Antibodypedia

 FOXA3 antibodies

PROTEIN BROWSER
FOXA3-001
FOXA3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXA3-001
ENSP00000304004
ENST00000302177
P55318 [Direct mapping]
Hepatocyte nuclear factor 3-gamma
A0A024R0R3 [Target identity:100%; Query identity:100%]
Forkhead box A3, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001678 [cellular glucose homeostasis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0008134 [transcription factor binding]
GO:0009267 [cellular response to starvation]
GO:0009653 [anatomical structure morphogenesis]
GO:0016568 [chromatin modification]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 350 aa
37.1 kDa 		No 0
FOXA3-002
ENSP00000470816
ENST00000594297
M0QZW5 [Direct mapping]
Hepatocyte nuclear factor 3-gamma
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Predicted intracellular proteins
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 102 aa
10.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.