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RASA4B

GENERAL INFORMATION

Gene name

 RASA4B

Gene description

 RAS p21 protein activator 4B

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (SH-SY5Y, U-138 MG, U-2 OS)
HPA (normal tissue):Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA043010
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043010

GENE INFORMATION

Gene name

 RASA4B

Synonyms

Description

 RAS p21 protein activator 4B (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 102482445 - 102517781

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000170667 (version 83.38)

Entrez gene

 100271927

UniProt

 C9J798 (UniProt - Inferred from homology)

neXtProt

 NX_C9J798

Antibodypedia

 RASA4B antibodies

PROTEIN BROWSER
RASA4B-001
RASA4B-003
RASA4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASA4B-001
ENSP00000417895
ENST00000465829
C9J798 [Direct mapping]
Ras GTPase-activating protein 4B
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
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 803 aa
90.4 kDa 		No 0
RASA4B-003
ENSP00000303968
ENST00000306682
F8W6L0 [Direct mapping]
Ras GTPase-activating protein 4B
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 731 aa
82.2 kDa 		No 0
RASA4B-201
ENSP00000440982
ENST00000541662
F5GXT2 [Direct mapping]
Ras GTPase-activating protein 4B
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 757 aa
85.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.