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Few cases of melanoma showed weak cytoplasmic and nuclear/ nucleolar staining. Few cases of pancreatic and testis cancer tissues showed weak membranous positivity. A single case of papillary adenocarcinoma of thyroid showed strong granular cytoplasmic positivity in a subset of cancer cells. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
GPR37 (HGNC Symbol)
Synonyms
EDNRBL, hET(B)R-LP, PAELR
Description
G protein-coupled receptor 37 (endothelin receptor type B-like) (HGNC Symbol)
Entrez gene summary
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]