Expression of AKAP13 in cancer - Summary - The Human Protein Atlas

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AKAP13

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AKAP13
Gene description	A kinase (PRKA) anchor protein 13
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA019773
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019773

GENE INFORMATION
Gene name	AKAP13 (HGNC Symbol)
Synonyms	AKAP-Lbc, ARHGEF13, BRX, c-lbc, HA-3, Ht31, LBC, PROTO-LB
Description	A kinase (PRKA) anchor protein 13 (HGNC Symbol)
Entrez gene summary	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Chromosome	15
Cytoband	q25.3
Chromosome location (bp)	85380571 - 85749358
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170776 (version 83.38)
Entrez gene	11214
UniProt	Q12802 (UniProt - Evidence at protein level)
neXtProt	NX_Q12802
Antibodypedia	AKAP13 antibodies

PROTEIN BROWSER

AKAP13-001	AKAP13-002	AKAP13-003	AKAP13-004	AKAP13-006	AKAP13-007	AKAP13-008	AKAP13-009	AKAP13-010	AKAP13-011	AKAP13-012	AKAP13-015	AKAP13-025	AKAP13-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP13-001 ENSP00000354718 ENST00000361243	Q12802 [Direct mapping] A-kinase anchor protein 13 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004691 [cAMP-dependent protein kinase activity] GO:0004871 [signal transducer activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007264 [small GTPase mediated signal transduction] GO:0010611 [regulation of cardiac muscle hypertrophy] GO:0016020 [membrane] GO:0017048 [Rho GTPase binding] GO:0032947 [protein complex scaffold] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0045859 [regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0051018 [protein kinase A binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0051168 [nuclear export] GO:0097190 [apoptotic signaling pathway] GO:1900169 [regulation of glucocorticoid mediated signaling pathway] Show all	2817 aa 307.8 kDa	No	0
AKAP13-002 ENSP00000453768 ENST00000559362	H0YMW2 [Direct mapping] A-kinase anchor protein 13 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1745 aa 186.1 kDa	No	0
AKAP13-003 ENSP00000453634 ENST00000560302	Q12802 [Direct mapping] A-kinase anchor protein 13 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004691 [cAMP-dependent protein kinase activity] GO:0004871 [signal transducer activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0035023 [regulation of Rho protein signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0097190 [apoptotic signaling pathway] Show all	179 aa 20 kDa	No	0
AKAP13-004 ENSP00000378026 ENST00000394518	Q12802 [Direct mapping] A-kinase anchor protein 13 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004691 [cAMP-dependent protein kinase activity] GO:0004871 [signal transducer activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0097190 [apoptotic signaling pathway] Show all	2813 aa 307.5 kDa	No	0
AKAP13-006 ENSP00000453620 ENST00000560256	H0YMI5 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.2 kDa	No	0
AKAP13-007 ENSP00000481485 ENST00000560676	A0A087WY36 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	967 aa 109 kDa	No	0
AKAP13-008 ENSP00000477780 ENST00000560579	A0A087WTD7 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	1429 aa 161.2 kDa	No	0
AKAP13-009 ENSP00000452622 ENST00000558166	H0YK18 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.2 kDa	No	0
AKAP13-010 ENSP00000452698 ENST00000558811	H0YK84 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16 kDa	No	0
AKAP13-011 ENSP00000483091 ENST00000560340	A0A087X047 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.7 kDa	No	0
AKAP13-012 ENSP00000453205 ENST00000559486	H0YLH1 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		275 aa 30.1 kDa	No	0
AKAP13-015 ENSP00000480789 ENST00000557852	A0A087WX73 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	166 aa 18.6 kDa	No	0
AKAP13-025 ENSP00000482058 ENST00000612418	A0A087WYS7 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.4 kDa	No	0
AKAP13-201 ENSP00000378018 ENST00000394510	A8MYJ1 [Direct mapping] A-kinase anchor protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005737 [cytoplasm] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	1434 aa 161.8 kDa	No	0

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