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LMOD2

GENERAL INFORMATION

Gene name

 LMOD2

Gene description

 Leiomodin 2 (cardiac)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (head and neck cancer, prostate cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA051039
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (head and neck cancer, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051039

GENE INFORMATION

Gene name

 LMOD2

Synonyms

Description

 Leiomodin 2 (cardiac) (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q31.32

Chromosome location (bp)

 123655807 - 123664290

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170807 (version 83.38)

Entrez gene

 442721

UniProt

 Q6P5Q4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P5Q4

Antibodypedia

 LMOD2 antibodies

PROTEIN BROWSER
LMOD2-002
LMOD2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMOD2-002
ENSP00000411932
ENST00000458573
Q6P5Q4 [Direct mapping]
Leiomodin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005856 [cytoskeleton]
GO:0005865 [striated muscle thin filament]
GO:0006936 [muscle contraction]
GO:0007015 [actin filament organization]
GO:0030016 [myofibril]
GO:0030239 [myofibril assembly]
GO:0051694 [pointed-end actin filament capping]
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 547 aa
61.7 kDa 		No 0
LMOD2-003
ENSP00000398975
ENST00000456238
C9J8F4 [Direct mapping]
Leiomodin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005856 [cytoskeleton]
GO:0005865 [striated muscle thin filament]
GO:0006936 [muscle contraction]
GO:0007015 [actin filament organization]
GO:0030016 [myofibril]
GO:0030239 [myofibril assembly]
GO:0051694 [pointed-end actin filament capping]
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 159 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.