We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
FSHR
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FSHR

Gene description

Follicle stimulating hormone receptor

Protein class

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (ovary, testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (gallbladder, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (ovary, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, testis)

GENE INFORMATION

Gene name

FSHR (HGNC Symbol)

Synonyms

FSHRO, LGR1, ODG1

Description

Follicle stimulating hormone receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

2

Cytoband

p16.3

Chromosome location (bp)

48962157 - 49154537

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170820 (version 83.38)

Entrez gene

2492

UniProt

P23945 (UniProt - Evidence at protein level)

neXtProt

NX_P23945

Antibodypedia

FSHR antibodies

PROTEIN BROWSER

FSHR-001
FSHR-002
FSHR-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FSHR-001
ENSP00000384708
ENST00000406846
A0A0A0MSC5 [Direct mapping]
Follicle-stimulating hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0001545 [primary ovarian follicle growth]
GO:0001932 [regulation of protein phosphorylation]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004963 [follicle-stimulating hormone receptor activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0007626 [locomotory behavior]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009986 [cell surface]
GO:0009992 [cellular water homeostasis]
GO:0010640 [regulation of platelet-derived growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0022602 [ovulation cycle process]
GO:0031175 [neuron projection development]
GO:0032350 [regulation of hormone metabolic process]
GO:0033044 [regulation of chromosome organization]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0035092 [sperm chromatin condensation]
GO:0035093 [spermatogenesis, exchange of chromosomal proteins]
GO:0042699 [follicle-stimulating hormone signaling pathway]
GO:0043408 [regulation of MAPK cascade]
GO:0045056 [transcytosis]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045779 [negative regulation of bone resorption]
GO:0060009 [Sertoli cell development]
GO:0060011 [Sertoli cell proliferation]
GO:0060065 [uterus development]
GO:0060408 [regulation of acetylcholine metabolic process]
GO:0071711 [basement membrane organization]
Show all
695 aa
78.2 kDa
Yes 7
FSHR-002
ENSP00000415504
ENST00000454032
C9JDA1 [Direct mapping]
Follicle-stimulating hormone receptor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001545 [primary ovarian follicle growth]
GO:0004963 [follicle-stimulating hormone receptor activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0009755 [hormone-mediated signaling pathway]
GO:0042699 [follicle-stimulating hormone signaling pathway]
GO:0045670 [regulation of osteoclast differentiation]
GO:0060065 [uterus development]
Show all
278 aa
31.5 kDa
Yes 0
FSHR-003
ENSP00000306780
ENST00000304421
P23945 [Direct mapping]
Follicle-stimulating hormone receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001545 [primary ovarian follicle growth]
GO:0004930 [G-protein coupled receptor activity]
GO:0004963 [follicle-stimulating hormone receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0007292 [female gamete generation]
GO:0008406 [gonad development]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0008584 [male gonad development]
GO:0008585 [female gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010738 [regulation of protein kinase A signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0042699 [follicle-stimulating hormone signaling pathway]
GO:0045670 [regulation of osteoclast differentiation]
GO:0060065 [uterus development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
669 aa
75.3 kDa
Yes 7

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.