Expression of PPM1D in cancer - Summary - The Human Protein Atlas

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PPM1D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPM1D
Gene description	Protein phosphatase, Mg2+/Mn2+ dependent, 1D
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA022277
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022277

GENE INFORMATION
Gene name	PPM1D (HGNC Symbol)
Synonyms	PP2C-DELTA, Wip1
Description	Protein phosphatase, Mg2+/Mn2+ dependent, 1D (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	60600183 - 60666280
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170836 (version 83.38)
Entrez gene	8493
UniProt	O15297 (UniProt - Evidence at protein level)
neXtProt	NX_O15297
Antibodypedia	PPM1D antibodies

PROTEIN BROWSER

PPM1D-001	PPM1D-004	PPM1D-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPM1D-001 ENSP00000306682 ENST00000305921	O15297 [Direct mapping] Protein phosphatase 1D Show all	Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006470 [protein dephosphorylation] GO:0008285 [negative regulation of cell proliferation] GO:0009267 [cellular response to starvation] GO:0009314 [response to radiation] GO:0009617 [response to bacterium] GO:0035970 [peptidyl-threonine dephosphorylation] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0051019 [mitogen-activated protein kinase binding] Show all	605 aa 66.7 kDa	No	0
PPM1D-004 ENSP00000465168 ENST00000590418	K7EJH1 [Direct mapping] Protein phosphatase 1D Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] Show all	126 aa 14 kDa	No	0
PPM1D-201 ENSP00000486573 ENST00000629650	O15297 [Direct mapping] Protein phosphatase 1D Show all	Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006470 [protein dephosphorylation] GO:0008285 [negative regulation of cell proliferation] GO:0009314 [response to radiation] GO:0035970 [peptidyl-threonine dephosphorylation] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0051019 [mitogen-activated protein kinase binding] Show all	430 aa 47.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.