Expression of GPR27 in cancer - Summary - The Human Protein Atlas

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GPR27

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR27
Gene description	G protein-coupled receptor 27
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (EFO-21, HL-60, NTERA-2)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA029395
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and breast cancer (favourable).
Ovarian cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029395

GENE INFORMATION
Gene name	GPR27 (HGNC Symbol)
Synonyms	SREB1
Description	G protein-coupled receptor 27 (HGNC Symbol)
Entrez gene summary	GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]
Chromosome	3
Cytoband	p13
Chromosome location (bp)	71754050 - 71756496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170837 (version 83.38)
Entrez gene	2850
UniProt	Q9NS67 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NS67
Antibodypedia	GPR27 antibodies

PROTEIN BROWSER

GPR27-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR27-001 ENSP00000303149 ENST00000304411	Q9NS67 [Direct mapping] Probable G-protein coupled receptor 27 F1DAM3 [Target identity:100%; Query identity:100%] G protein-coupled receptor 27 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:1900738 [positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway] Show all	375 aa 39.8 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.