Expression of KBTBD2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

KBTBD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KBTBD2
Gene description	Kelch repeat and BTB (POZ) domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA021133
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and liver cancer (unfavourable).
Cervical cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021133

GENE INFORMATION
Gene name	KBTBD2 (HGNC Symbol)
Synonyms	BKLHD1, DKFZP566C134
Description	Kelch repeat and BTB (POZ) domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	32868172 - 32894131
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170852 (version 83.38)
Entrez gene	25948
UniProt	Q8IY47 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IY47
Antibodypedia	KBTBD2 antibodies

PROTEIN BROWSER

KBTBD2-001	KBTBD2-002	KBTBD2-003	KBTBD2-004	KBTBD2-005	KBTBD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KBTBD2-001 ENSP00000302586 ENST00000304056	Q8IY47 [Direct mapping] Kelch repeat and BTB domain-containing protein 2 A0A024RA38 [Target identity:100%; Query identity:100%] Kelch repeat and BTB (POZ) domain containing 2; Kelch repeat and BTB (POZ) domain containing 2, isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	623 aa 71.3 kDa	No	0
KBTBD2-002 ENSP00000407059 ENST00000453627	C9JZ29 [Direct mapping] Kelch repeat and BTB domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	29 aa 3.5 kDa	No	0
KBTBD2-003 ENSP00000388236 ENST00000424468		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		4 aa 0.5 kDa	No	0
KBTBD2-004 ENSP00000395715 ENST00000452926	C9JI11 [Direct mapping] Kelch repeat and BTB domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	48 aa 5.7 kDa	No	0
KBTBD2-005 ENSP00000407520 ENST00000423022	C9JUE5 [Direct mapping] Kelch repeat and BTB domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	14 aa 1.7 kDa	No	0
KBTBD2-201 ENSP00000481197 ENST00000621876	A0A087WXP9 [Direct mapping] Kelch repeat and BTB domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	334 aa 38.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.