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MINA

GENERAL INFORMATION

Gene name

 MINA

Gene description

 MYC induced nuclear antigen

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA007603 , HPA008080 , CAB013458
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA007603
HPA008080
CAB013458

GENE INFORMATION

Gene name

 MINA (HGNC Symbol)

Synonyms

 FLJ14393, mdig, MINA53

Description

 MYC induced nuclear antigen (HGNC Symbol)

Entrez gene summary

 MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

Chromosome

 3

Cytoband

 q11.2

Chromosome location (bp)

 97941818 - 97972457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170854 (version 83.38)

Entrez gene

 84864

UniProt

 Q8IUF8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IUF8

Antibodypedia

 MINA antibodies

PROTEIN BROWSER
MINA-001
MINA-002
MINA-003
MINA-007
MINA-008
MINA-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MINA-001
ENSP00000377748
ENST00000394198
Q8IUF8 [Direct mapping]
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0042254 [ribosome biogenesis]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
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 465 aa
52.8 kDa 		No 0
MINA-002
ENSP00000328251
ENST00000333396
Q8IUF8 [Direct mapping]
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0042254 [ribosome biogenesis]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
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 465 aa
52.8 kDa 		No 0
MINA-003
ENSP00000353395
ENST00000360258
Q8IUF8 [Direct mapping]
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0042254 [ribosome biogenesis]
GO:0046872 [metal ion binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
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 464 aa
52.7 kDa 		No 0
MINA-007
ENSP00000424530
ENST00000507612
H0Y9L8 [Direct mapping]
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
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 108 aa
12.2 kDa 		No 0
MINA-008
ENSP00000421347
ENST00000503097
H0Y8K4 [Direct mapping]
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 27 aa
3.2 kDa 		No 0
MINA-010
ENSP00000423816
ENST00000506099
D6RCB6 [Direct mapping]
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 112 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.