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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TRIAP1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TRIAP1

Gene description

TP53 regulated inhibitor of apoptosis 1

Protein class

Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA053640
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PROGNOSTIC SUMMARY

Prognostic marker in melanoma (unfavourable) and renal cancer (unfavourable).
Melanoma p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA053640

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed moderate cytoplasmic positivity. A few hepatocellular carcinomas showed strong staining. Several carcinoids, gliomas and cervical cancers were weakly stained.

GENE INFORMATION

Gene name

TRIAP1 (HGNC Symbol)

Synonyms

HSPC132, MDM35, P53CSV, WF-1

Description

TP53 regulated inhibitor of apoptosis 1 (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

120443961 - 120446412

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170855 (version 83.38)

Entrez gene

51499

UniProt

O43715 (UniProt - Evidence at protein level)

neXtProt

NX_O43715

Antibodypedia

TRIAP1 antibodies

PROTEIN BROWSER

TRIAP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIAP1-001
ENSP00000449795
ENST00000546954
O43715 [Direct mapping]
TP53-regulated inhibitor of apoptosis 1
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0015914 [phospholipid transport]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0034644 [cellular response to UV]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097035 [regulation of membrane lipid distribution]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:1990050 [phosphatidic acid transporter activity]
GO:2001140 [positive regulation of phospholipid transport]
Show all
76 aa
8.8 kDa
No 0

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