Expression of CYTL1 in cancer - Summary - The Human Protein Atlas

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CYTL1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CYTL1
Gene description	Cytokine-like 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma, melanoma)
HPA (cell line):	Cell line enhanced (HEL, HUVEC TERT2, NB-4, WM-115)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable), urothelial cancer (unfavourable) and renal cancer (unfavourable).
Stomach cancer p<0.001 Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma, melanoma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CYTL1 (HGNC Symbol)
Synonyms	C17, C4orf4
Description	Cytokine-like 1 (HGNC Symbol)
Entrez gene summary	C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	p16.2
Chromosome location (bp)	5014586 - 5019472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170891 (version 83.38)
Entrez gene	54360
UniProt	Q9NRR1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRR1
Antibodypedia	CYTL1 antibodies

PROTEIN BROWSER

CYTL1-001	CYTL1-003	CYTL1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYTL1-001 ENSP00000303550 ENST00000307746	Q9NRR1 [Direct mapping] Cytokine-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002062 [chondrocyte differentiation] GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048839 [inner ear development] GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1990079 [cartilage homeostasis] Show all	136 aa 15.6 kDa	Yes	0
CYTL1-003 ENSP00000425397 ENST00000506508	H0Y9X7 [Direct mapping] Cytokine-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.3 kDa	Yes	0
CYTL1-004 ENSP00000421743 ENST00000509419	H0Y8Q4 [Direct mapping] Cytokine-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.