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TSEN34

GENERAL INFORMATION

Gene name

 TSEN34

Gene description

 TSEN34 tRNA splicing endonuclease subunit

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA041111
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TSEN34 (HGNC Symbol)

Synonyms

 LENG5, SEN34, SEN34L

Description

 TSEN34 tRNA splicing endonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 54189938 - 54194536

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170892 (version 83.38)

Entrez gene

 79042

UniProt

 Q9BSV6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BSV6

Antibodypedia

 TSEN34 antibodies

PROTEIN BROWSER
TSEN34-001
TSEN34-003
TSEN34-004
TSEN34-005
TSEN34-006
TSEN34-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSEN34-001
ENSP00000305524
ENST00000302937
Q9BSV6 [Direct mapping]
tRNA-splicing endonuclease subunit Sen34
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 310 aa
33.7 kDa 		No 0
TSEN34-003
ENSP00000379667
ENST00000396383
Q9BSV6 [Direct mapping]
tRNA-splicing endonuclease subunit Sen34
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 310 aa
33.7 kDa 		No 0
TSEN34-004
ENSP00000379671
ENST00000396388
Q9BSV6 [Direct mapping]
tRNA-splicing endonuclease subunit Sen34
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 310 aa
33.7 kDa 		No 0
TSEN34-005
ENSP00000408689
ENST00000456872
A9C4B9 [Direct mapping]
tRNA-splicing endonuclease subunit Sen34
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 251 aa
27.3 kDa 		No 0
TSEN34-006
ENSP00000400743
ENST00000455798
B0V3J0 [Direct mapping]
tRNA-splicing endonuclease subunit Sen34
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 242 aa
26.1 kDa 		No 0
TSEN34-201
ENSP00000397402
ENST00000429671
E7EQB3 [Direct mapping]
tRNA-splicing endonuclease subunit Sen34
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 315 aa
34.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.