Expression of GSTA4 in cancer - Summary - The Human Protein Atlas

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GSTA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GSTA4
Gene description	Glutathione S-transferase alpha 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA048934
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048934

GENE INFORMATION
Gene name	GSTA4
Synonyms
Description	Glutathione S-transferase alpha 4 (HGNC Symbol)
Entrez gene summary	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p12.2
Chromosome location (bp)	52977948 - 52995378
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170899 (version 83.38)
Entrez gene	2941
UniProt	O15217 (UniProt - Evidence at protein level)
neXtProt	NX_O15217
Antibodypedia	GSTA4 antibodies

PROTEIN BROWSER

GSTA4-001	GSTA4-003	GSTA4-004	GSTA4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSTA4-001 ENSP00000360002 ENST00000370963	O15217 [Direct mapping] Glutathione S-transferase A4 A0A024RD58 [Target identity:100%; Query identity:100%] Glutathione S-transferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	222 aa 25.7 kDa	No	0
GSTA4-003 ENSP00000359998 ENST00000370959	O15217 [Direct mapping] Glutathione S-transferase A4 A0A024RD58 [Target identity:100%; Query identity:100%] Glutathione S-transferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	222 aa 25.7 kDa	No	0
GSTA4-004 ENSP00000359999 ENST00000370960	O15217 [Direct mapping] Glutathione S-transferase A4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	129 aa 14.9 kDa	No	0
GSTA4-005 ENSP00000394228 ENST00000457564	Q5JW88 [Direct mapping] Glutathione S-transferase A4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.