Expression of CEACAM3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CEACAM3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEACAM3
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 3
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in gastrointestinal tract and in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA011041
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011041

GENE INFORMATION
Gene name	CEACAM3 (HGNC Symbol)
Synonyms	CD66d, CGM1
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41796437 - 41811553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170956 (version 83.38)
Entrez gene	1084
UniProt	P40198 (UniProt - Evidence at protein level)
neXtProt	NX_P40198
Antibodypedia	CEACAM3 antibodies

PROTEIN BROWSER

CEACAM3-001	CEACAM3-002	CEACAM3-006	CEACAM3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM3-001 ENSP00000349971 ENST00000357396	P40198 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	252 aa 27.1 kDa	Yes	1
CEACAM3-002 ENSP00000341725 ENST00000344550	P40198 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	212 aa 22.8 kDa	Yes	1
CEACAM3-006 ENSP00000469333 ENST00000596544	M0QXR5 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	99 aa 10.9 kDa	No	0
CEACAM3-201 ENSP00000485920 ENST00000630848	P40198 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	212 aa 22.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.