Cell atlas - PDGFD - The Human Protein Atlas

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PDGFD

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	PDGFD
Gene description	Platelet derived growth factor D
Protein class	Predicted intracellular proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & vesicles.
RNA cell category	Cell line enhanced (SK-BR-3, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046183
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-BR-3, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & vesicles.

Main location

Golgi apparatus (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046183	A-431	Vesicles
	HPA046183	A549	Golgi apparatus
	HPA046183	U-2 OS	Vesicles

GENE INFORMATION
Gene name	PDGFD (HGNC Symbol)
Synonyms	IEGF, MSTP036, SCDGF-B
Description	Platelet derived growth factor D (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q22.3
Chromosome location (bp)	103907186 - 104164379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170962 (version 83.38)
Entrez gene	80310
UniProt	Q9GZP0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZP0
Antibodypedia	PDGFD antibodies

PROTEIN BROWSER

PDGFD-001	PDGFD-002	PDGFD-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDGFD-001 ENSP00000376865 ENST00000393158	Q9GZP0 [Direct mapping] Platelet-derived growth factor D Platelet-derived growth factor D, latent form Platelet-derived growth factor D, receptor-binding form Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0016020 [membrane] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0051781 [positive regulation of cell division] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0071230 [cellular response to amino acid stimulus] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071673 [positive regulation of smooth muscle cell chemotaxis] GO:0072126 [positive regulation of glomerular mesangial cell proliferation] GO:2000439 [positive regulation of monocyte extravasation] Show all	370 aa 42.8 kDa	Yes	0
PDGFD-002 ENSP00000302193 ENST00000302251	Q9GZP0 [Direct mapping] Platelet-derived growth factor D Platelet-derived growth factor D, latent form Platelet-derived growth factor D, receptor-binding form Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0016020 [membrane] GO:0051781 [positive regulation of cell division] GO:0070062 [extracellular exosome] Show all	364 aa 42.2 kDa	Yes	0
PDGFD-003 ENSP00000432909 ENST00000529268	H0YD37 [Direct mapping] Platelet-derived growth factor D Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		206 aa 23.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.