Cell atlas - HS6ST2 - The Human Protein Atlas

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HS6ST2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HS6ST2
Gene description	Heparan sulfate 6-O-sulfotransferase 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (SH-SY5Y, RH-30, HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA034625 , HPA034626
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, RH-30, HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034625	A-431	Nucleoplasm
	HPA034625	U-2 OS	Nucleoplasm
	HPA034625	U-251 MG	Nucleoplasm
	HPA034626	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	HS6ST2
Synonyms
Description	Heparan sulfate 6-O-sulfotransferase 2 (HGNC Symbol)
Entrez gene summary	Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q26.2
Chromosome location (bp)	132626016 - 132961395
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171004 (version 83.38)
Entrez gene	90161
UniProt	Q96MM7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96MM7
Antibodypedia	HS6ST2 antibodies

PROTEIN BROWSER

HS6ST2-002	HS6ST2-004	HS6ST2-201	HS6ST2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS6ST2-002 ENSP00000359873 ENST00000370836	Q96MM7 [Direct mapping] Heparan-sulfate 6-O-sulfotransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005654 [nucleoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0015015 [heparan sulfate proteoglycan biosynthetic process, enzymatic modification] GO:0016021 [integral component of membrane] GO:0017095 [heparan sulfate 6-O-sulfotransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	605 aa 69.1 kDa	No	1
HS6ST2-004 ENSP00000429473 ENST00000521489	Q96MM7 [Direct mapping] Heparan-sulfate 6-O-sulfotransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005654 [nucleoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0015015 [heparan sulfate proteoglycan biosynthetic process, enzymatic modification] GO:0016021 [integral component of membrane] GO:0017095 [heparan sulfate 6-O-sulfotransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	645 aa 73.4 kDa	No	1
HS6ST2-201 ENSP00000359870 ENST00000370833	Q96MM7 [Direct mapping] Heparan-sulfate 6-O-sulfotransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005654 [nucleoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0015015 [heparan sulfate proteoglycan biosynthetic process, enzymatic modification] GO:0016021 [integral component of membrane] GO:0017095 [heparan sulfate 6-O-sulfotransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	645 aa 73.4 kDa	No	1
HS6ST2-202 ENSP00000384013 ENST00000406696	Q96MM7 [Direct mapping] Heparan-sulfate 6-O-sulfotransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005654 [nucleoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0015015 [heparan sulfate proteoglycan biosynthetic process, enzymatic modification] GO:0016021 [integral component of membrane] GO:0017095 [heparan sulfate 6-O-sulfotransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	605 aa 69.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.