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Protein kinase (cAMP-dependent, catalytic) inhibitor alpha (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006469 [negative regulation of protein kinase activity] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0034236 [protein kinase A catalytic subunit binding] GO:0042308 [negative regulation of protein import into nucleus] GO:0043086 [negative regulation of catalytic activity] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
