Expression of FPR1 in cancer - Summary - The Human Protein Atlas

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FPR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FPR1
Gene description	Formyl peptide receptor 1
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (U-87 MG)
HPA (normal tissue):	Tissue enhanced (appendix)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a group of tissues, including hematopoietic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA046550
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046550

GENE INFORMATION
Gene name	FPR1 (HGNC Symbol)
Synonyms	FMLP, FPR
Description	Formyl peptide receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51745172 - 51804110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171051 (version 83.38)
Entrez gene	2357
UniProt	P21462 (UniProt - Evidence at protein level)
neXtProt	NX_P21462
Antibodypedia	FPR1 antibodies

PROTEIN BROWSER

FPR1-001	FPR1-002	FPR1-003	FPR1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FPR1-001 ENSP00000302707 ENST00000304748	P21462 [Direct mapping] fMet-Leu-Phe receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004982 [N-formyl peptide receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007263 [nitric oxide mediated signal transduction] GO:0016021 [integral component of membrane] Show all	350 aa 38.4 kDa	No	7
FPR1-002 ENSP00000472936 ENST00000600815	M0R315 [Direct mapping] fMet-Leu-Phe receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004982 [N-formyl peptide receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	191 aa 21.1 kDa	No	4
FPR1-003 ENSP00000471493 ENST00000595042	P21462 [Direct mapping] fMet-Leu-Phe receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004982 [N-formyl peptide receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007263 [nitric oxide mediated signal transduction] GO:0016021 [integral component of membrane] GO:0050786 [RAGE receptor binding] Show all	350 aa 38.4 kDa	No	7
FPR1-004 ENSP00000470750 ENST00000594900	M0QZT0 [Direct mapping] fMet-Leu-Phe receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004982 [N-formyl peptide receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	40 aa 4.2 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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