We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
INSR
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

INSR

Gene description

Insulin receptor

Protein class

CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA036302
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

INSR (HGNC Symbol)

Synonyms

CD220

Description

Insulin receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

7112255 - 7294034

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171105 (version 83.38)

Entrez gene

3643

UniProt

P06213 (UniProt - Evidence at protein level)

neXtProt

NX_P06213

Antibodypedia

INSR antibodies

PROTEIN BROWSER

INSR-001
INSR-002
INSR-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INSR-001
ENSP00000303830
ENST00000302850
P06213 [Direct mapping]
Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005009 [insulin-activated receptor activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005901 [caveola]
GO:0005975 [carbohydrate metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008544 [epidermis development]
GO:0008584 [male gonad development]
GO:0009725 [response to hormone]
GO:0009887 [organ morphogenesis]
GO:0010008 [endosome membrane]
GO:0010042 [response to manganese ion]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0010629 [negative regulation of gene expression]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019087 [transformation of host cell by virus]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019904 [protein domain specific binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030238 [male sex determination]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0031017 [exocrine pancreas development]
GO:0031405 [lipoic acid binding]
GO:0031667 [response to nutrient levels]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0032147 [activation of protein kinase activity]
GO:0032148 [activation of protein kinase B activity]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0032410 [negative regulation of transporter activity]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0033280 [response to vitamin D]
GO:0033574 [response to testosterone]
GO:0034612 [response to tumor necrosis factor]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042593 [glucose homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043423 [3-phosphoinositide-dependent protein kinase binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0045202 [synapse]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045444 [fat cell differentiation]
GO:0045471 [response to ethanol]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045995 [regulation of embryonic development]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0048639 [positive regulation of developmental growth]
GO:0051290 [protein heterotetramerization]
GO:0051384 [response to glucocorticoid]
GO:0051425 [PTB domain binding]
GO:0051446 [positive regulation of meiotic cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060267 [positive regulation of respiratory burst]
GO:0070062 [extracellular exosome]
GO:0071363 [cellular response to growth factor stimulus]
GO:2000194 [regulation of female gonad development]
Show all
1382 aa
156.3 kDa
Yes 1
INSR-002
ENSP00000342838
ENST00000341500
P06213 [Direct mapping]
Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005009 [insulin-activated receptor activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005901 [caveola]
GO:0005975 [carbohydrate metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019087 [transformation of host cell by virus]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030335 [positive regulation of cell migration]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0032147 [activation of protein kinase activity]
GO:0032148 [activation of protein kinase B activity]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045995 [regulation of embryonic development]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0048639 [positive regulation of developmental growth]
GO:0051290 [protein heterotetramerization]
GO:0051425 [PTB domain binding]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060267 [positive regulation of respiratory burst]
GO:0070062 [extracellular exosome]
Show all
1370 aa
155.1 kDa
Yes 1
INSR-004
ENSP00000473170
ENST00000600492
M0R3E6 [Direct mapping]
Insulin receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
152 aa
17.2 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.