Cell atlas - NRTN - The Human Protein Atlas

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NRTN

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	NRTN
Gene description	Neurturin
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (REH, SH-SY5Y, U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA065260
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, SH-SY5Y, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065260	SH-SY5Y	Golgi apparatus

GENE INFORMATION
Gene name	NRTN (HGNC Symbol)
Synonyms	NTN
Description	Neurturin (HGNC Symbol)
Entrez gene summary	Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5823802 - 5828324
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171119 (version 83.38)
Entrez gene	4902
UniProt	Q99748 (UniProt - Evidence at protein level)
neXtProt	NX_Q99748
Antibodypedia	NRTN antibodies

PROTEIN BROWSER

NRTN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRTN-001 ENSP00000302648 ENST00000303212	Q99748 [Direct mapping] Neurturin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0000165 [MAPK cascade] GO:0001755 [neural crest cell migration] GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0021675 [nerve development] GO:0030424 [axon] GO:0031175 [neuron projection development] Show all	197 aa 22.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.