Tissue expression of KCNMB3 - Summary - The Human Protein Atlas

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KCNMB3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KCNMB3
Gene description	Potassium channel subfamily M regulatory beta subunit 3
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA015665 , HPA019185
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	KCNMB3 (HGNC Symbol)
Synonyms	KCNMB2, KCNMBL
Description	Potassium channel subfamily M regulatory beta subunit 3 (HGNC Symbol)
Entrez gene summary	MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
Chromosome	3
Cytoband	q26.32
Chromosome location (bp)	179236691 - 179267002
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171121 (version 83.38)
Entrez gene	27094
UniProt	Q9NPA1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPA1
Antibodypedia	KCNMB3 antibodies

PROTEIN BROWSER

KCNMB3-001	KCNMB3-002	KCNMB3-004	KCNMB3-005	KCNMB3-006	KCNMB3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNMB3-001 ENSP00000418536 ENST00000485523	Q9NPA1 [Direct mapping] Calcium-activated potassium channel subunit beta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0001508 [action potential] GO:0004427 [inorganic diphosphatase activity] GO:0005513 [detection of calcium ion] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006796 [phosphate-containing compound metabolic process] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0071805 [potassium ion transmembrane transport] Show all	257 aa 29 kDa	No	2
KCNMB3-002 ENSP00000417091 ENST00000497599	Q9NPA1 [Direct mapping] Calcium-activated potassium channel subunit beta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0071805 [potassium ion transmembrane transport] Show all	173 aa 19.5 kDa	No	1
KCNMB3-004 ENSP00000319370 ENST00000314235	Q9NPA1 [Direct mapping] Calcium-activated potassium channel subunit beta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0071805 [potassium ion transmembrane transport] Show all	279 aa 31.6 kDa	No	2
KCNMB3-005 ENSP00000376451 ENST00000392685	Q9NPA1 [Direct mapping] Calcium-activated potassium channel subunit beta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0001508 [action potential] GO:0004427 [inorganic diphosphatase activity] GO:0005513 [detection of calcium ion] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006796 [phosphate-containing compound metabolic process] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0071805 [potassium ion transmembrane transport] Show all	275 aa 31.1 kDa	No	2
KCNMB3-006 ENSP00000479162 ENST00000486944	A0A087WV41 [Direct mapping] Calcium-activated potassium channel subunit beta-3 Show all	Predicted intracellular proteins Show all	GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	64 aa 7.4 kDa	No	0
KCNMB3-007 ENSP00000327866 ENST00000349697	Q9NPA1 [Direct mapping] Calcium-activated potassium channel subunit beta-3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0001508 [action potential] GO:0005513 [detection of calcium ion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0071805 [potassium ion transmembrane transport] Show all	277 aa 31.4 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.