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TADA3

GENERAL INFORMATION

Gene name

 TADA3

Gene description

 Transcriptional adaptor 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA042250
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042250

GENE INFORMATION

Gene name

 TADA3 (HGNC Symbol)

Synonyms

 ADA3, FLJ20221, FLJ21329, hADA3, NGG1, TADA3L

Description

 Transcriptional adaptor 3 (HGNC Symbol)

Entrez gene summary

 DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 9779860 - 9793011

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171148 (version 83.38)

Entrez gene

 10474

UniProt

 O75528 (UniProt - Evidence at protein level)

neXtProt

 NX_O75528

Antibodypedia

 TADA3 antibodies

PROTEIN BROWSER
TADA3-001
TADA3-002
TADA3-004
TADA3-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TADA3-001
ENSP00000307684
ENST00000301964
O75528 [Direct mapping]
Transcriptional adapter 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0010628 [positive regulation of gene expression]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019904 [protein domain specific binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030914 [STAGA complex]
GO:0031063 [regulation of histone deacetylation]
GO:0031647 [regulation of protein stability]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0072686 [mitotic spindle]
GO:0090043 [regulation of tubulin deacetylation]
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 432 aa
48.9 kDa 		No 0
TADA3-002
ENSP00000343649
ENST00000343450
O75528 [Direct mapping]
Transcriptional adapter 3
A0A024R2D7 [Target identity:100%; Query identity:100%]
Transcriptional adaptor 3 (NGG1 homolog, yeast)-like, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0010628 [positive regulation of gene expression]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019904 [protein domain specific binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
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 369 aa
41.4 kDa 		No 0
TADA3-004
ENSP00000393471
ENST00000440161
O75528 [Direct mapping]
Transcriptional adapter 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0010628 [positive regulation of gene expression]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019904 [protein domain specific binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 432 aa
48.9 kDa 		No 0
TADA3-009
ENSP00000395073
ENST00000439043
C9JMS0 [Direct mapping]
Transcriptional adapter 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 95 aa
10.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.