Expression of MUC7 in cancer - Summary - The Human Protein Atlas

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MUC7

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MUC7
Gene description	Mucin 7, secreted
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, melanoma)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High and selective expression in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA006411
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006411

GENE INFORMATION
Gene name	MUC7 (HGNC Symbol)
Synonyms	FLJ27047, MG2
Description	Mucin 7, secreted (HGNC Symbol)
Entrez gene summary	This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70430492 - 70482997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171195 (version 83.38)
Entrez gene	4589
UniProt	Q8TAX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAX7
Antibodypedia	MUC7 antibodies

PROTEIN BROWSER

MUC7-001	MUC7-002	MUC7-201	MUC7-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MUC7-001 ENSP00000302021 ENST00000304887	Q8TAX7 [Direct mapping] Mucin-7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005796 [Golgi lumen] GO:0006493 [protein O-linked glycosylation] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	377 aa 39.2 kDa	Yes	0
MUC7-002 ENSP00000427594 ENST00000505411	D6RHX1 [Direct mapping] Mucin-7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.5 kDa	Yes	0
MUC7-201 ENSP00000407422 ENST00000413702	Q8TAX7 [Direct mapping] Mucin-7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005796 [Golgi lumen] GO:0006493 [protein O-linked glycosylation] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	377 aa 39.2 kDa	Yes	0
MUC7-202 ENSP00000400585 ENST00000456088	Q8TAX7 [Direct mapping] Mucin-7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005796 [Golgi lumen] GO:0006493 [protein O-linked glycosylation] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	377 aa 39.2 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.