Expression of NETO2 in cancer - Summary - The Human Protein Atlas

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NETO2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NETO2
Gene description	Neuropilin (NRP) and tolloid (TLL)-like 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA013180
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013180

GENE INFORMATION
Gene name	NETO2 (HGNC Symbol)
Synonyms	FLJ10430, NEOT2
Description	Neuropilin (NRP) and tolloid (TLL)-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	47077703 - 47143997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171208 (version 83.38)
Entrez gene	81831
UniProt	Q8NC67 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NC67
Antibodypedia	NETO2 antibodies

PROTEIN BROWSER

NETO2-001	NETO2-002	NETO2-003	NETO2-004	NETO2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NETO2-001 ENSP00000455169 ENST00000562435	Q8NC67 [Direct mapping] Neuropilin and tolloid-like protein 2 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0014069 [postsynaptic density] GO:0032983 [kainate selective glutamate receptor complex] GO:0035255 [ionotropic glutamate receptor binding] GO:0045202 [synapse] GO:2000312 [regulation of kainate selective glutamate receptor activity] Show all	525 aa 59.4 kDa	Yes	1
NETO2-002 ENSP00000306726 ENST00000303155	Q8NC67 [Direct mapping] Neuropilin and tolloid-like protein 2 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0032983 [kainate selective glutamate receptor complex] GO:2000312 [regulation of kainate selective glutamate receptor activity] Show all	518 aa 58.7 kDa	Yes	1
NETO2-003 ENSP00000454213 ENST00000562559	H3BM37 [Direct mapping] Neuropilin and tolloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	365 aa 41.4 kDa	No	1
NETO2-004 ENSP00000456818 ENST00000563078	H3BSR0 [Direct mapping] Neuropilin and tolloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0032983 [kainate selective glutamate receptor complex] GO:2000312 [regulation of kainate selective glutamate receptor activity] Show all	194 aa 21.6 kDa	No	1
NETO2-005 ENSP00000457133 ENST00000564667	H3BTE1 [Direct mapping] Neuropilin and tolloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	228 aa 25.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.