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CDC42BPG

GENERAL INFORMATION

Gene name

 CDC42BPG

Gene description

 CDC42 binding protein kinase gamma (DMPK-like)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BEWO, HaCaT, MCF7)
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including skin.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA027382 , HPA061836
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027382
HPA061836

GENE INFORMATION

Gene name

 CDC42BPG (HGNC Symbol)

Synonyms

 DMPK2, HSMDPKIN, kappa-200, MRCKgamma

Description

 CDC42 binding protein kinase gamma (DMPK-like) (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64823387 - 64844569

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171219 (version 83.38)

Entrez gene

 55561

UniProt

 Q6DT37 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6DT37

Antibodypedia

 CDC42BPG antibodies

PROTEIN BROWSER
CDC42BPG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42BPG-001
ENSP00000345133
ENST00000342711
Q6DT37 [Direct mapping]
Serine/threonine-protein kinase MRCK gamma
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
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 1551 aa
172.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.