Expression of CANT1 in cancer - Summary - The Human Protein Atlas

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CANT1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CANT1
Gene description	Calcium activated nucleotidase 1
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, predominantly in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA019627 , HPA019639 , HPA022818
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), lung cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Lung cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019627	HPA019639	HPA022818

GENE INFORMATION
Gene name	CANT1 (HGNC Symbol)
Synonyms	SCAN-1, SHAPY
Description	Calcium activated nucleotidase 1 (HGNC Symbol)
Entrez gene summary	This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78991717 - 79009867
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171302 (version 83.38)
Entrez gene	124583
UniProt	Q8WVQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVQ1
Antibodypedia	CANT1 antibodies

PROTEIN BROWSER

CANT1-001	CANT1-002	CANT1-003	CANT1-006	CANT1-008	CANT1-011	CANT1-016	CANT1-018	CANT1-020	CANT1-021	CANT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CANT1-001 ENSP00000376241 ENST00000392446	Q8WVQ1 [Direct mapping] Soluble calcium-activated nucleotidase 1 A0A024R8U8 [Target identity:100%; Query identity:100%] Calcium activated nucleotidase 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004382 [guanosine-diphosphatase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0030166 [proteoglycan biosynthetic process] GO:0032580 [Golgi cisterna membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045134 [uridine-diphosphatase activity] GO:0070062 [extracellular exosome] Show all	401 aa 44.8 kDa	No	1
CANT1-002 ENSP00000467437 ENST00000591773	Q8WVQ1 [Direct mapping] Soluble calcium-activated nucleotidase 1 A0A024R8U8 [Target identity:100%; Query identity:100%] Calcium activated nucleotidase 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004382 [guanosine-diphosphatase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0030166 [proteoglycan biosynthetic process] GO:0032580 [Golgi cisterna membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045134 [uridine-diphosphatase activity] GO:0070062 [extracellular exosome] Show all	401 aa 44.8 kDa	No	1
CANT1-003 ENSP00000307674 ENST00000302345	Q8WVQ1 [Direct mapping] Soluble calcium-activated nucleotidase 1 A0A024R8U8 [Target identity:100%; Query identity:100%] Calcium activated nucleotidase 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004382 [guanosine-diphosphatase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0030166 [proteoglycan biosynthetic process] GO:0032580 [Golgi cisterna membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045134 [uridine-diphosphatase activity] GO:0070062 [extracellular exosome] Show all	401 aa 44.8 kDa	No	1
CANT1-006 ENSP00000464841 ENST00000591811	K7EIP9 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.2 kDa	No	0
CANT1-008 ENSP00000465769 ENST00000588075	K7EKT2 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] Show all	76 aa 8.5 kDa	No	1
CANT1-011 ENSP00000467886 ENST00000592033	K7EIP9 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.2 kDa	No	0
CANT1-016 ENSP00000465816 ENST00000588611	K7EKW6 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016462 [pyrophosphatase activity] Show all	118 aa 13.1 kDa	No	0
CANT1-018 ENSP00000467777 ENST00000591625	K7EQD4 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.8 kDa	No	0
CANT1-020 ENSP00000466637 ENST00000590370	K7EMT2 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] Show all	65 aa 7.4 kDa	No	1
CANT1-021 ENSP00000467970 ENST00000586916	K7EQT4 [Direct mapping] Soluble calcium-activated nucleotidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] Show all	61 aa 6.9 kDa	No	1
CANT1-201 ENSP00000477798 ENST00000620915	Q8WVQ1 [Direct mapping] Soluble calcium-activated nucleotidase 1 A0A024R8U8 [Target identity:100%; Query identity:100%] Calcium activated nucleotidase 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004382 [guanosine-diphosphatase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0030166 [proteoglycan biosynthetic process] GO:0032580 [Golgi cisterna membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045134 [uridine-diphosphatase activity] GO:0070062 [extracellular exosome] Show all	401 aa 44.8 kDa	No	1

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