Tissue expression of KCNK3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNK3
Gene description	Potassium channel, two pore domain subfamily K, member 3
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adrenal gland, placenta)
GTEx:	Tissue enriched (adrenal gland)
FANTOM5:	Tissue enhanced (pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (adrenal gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas)

GENE INFORMATION
Gene name	KCNK3 (HGNC Symbol)
Synonyms	K2p3.1, TASK, TASK-1
Description	Potassium channel, two pore domain subfamily K, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	26692690 - 26733420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171303 (version 83.38)
Entrez gene	3777
UniProt	O14649 (UniProt - Evidence at protein level)
neXtProt	NX_O14649
Antibodypedia	KCNK3 antibodies

PROTEIN BROWSER

KCNK3-001	KCNK3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK3-001 ENSP00000306275 ENST00000302909	O14649 [Direct mapping] Potassium channel subfamily K member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005252 [open rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007420 [brain development] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034220 [ion transmembrane transport] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0044548 [S100 protein binding] GO:0046982 [protein heterodimerization activity] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0071294 [cellular response to zinc ion] GO:0071456 [cellular response to hypoxia] GO:0071805 [potassium ion transmembrane transport] GO:0090102 [cochlea development] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	394 aa 43.5 kDa	No	5
KCNK3-201 ENSP00000483136 ENST00000620977	B9EIJ4 [Direct mapping] KCNK3 protein; Potassium channel subfamily K member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005252 [open rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	271 aa 29.6 kDa	No	3