Expression of CHST11 in cancer - Summary - The Human Protein Atlas

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CHST11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHST11
Gene description	Carbohydrate (chondroitin 4) sulfotransferase 11
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA052828
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052828

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer tissues showed weak to moderate granular cytoplasmic and occasional nuclear positivity. A few hepatocellular cancers showed strong positivity. Lymphomas, melanomas, testicular, urothelial, thyroid and head and neck cancers were mainly negative.

GENE INFORMATION
Gene name	CHST11 (HGNC Symbol)
Synonyms	C4ST, C4St-1, C4ST1, HSA269537
Description	Carbohydrate (chondroitin 4) sulfotransferase 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	104455295 - 104762014
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171310 (version 83.38)
Entrez gene	50515
UniProt	Q9NPF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPF2
Antibodypedia	CHST11 antibodies

PROTEIN BROWSER

CHST11-001	CHST11-002	CHST11-005	CHST11-006	CHST11-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST11-001 ENSP00000305725 ENST00000303694	Q9NPF2 [Direct mapping] Carbohydrate sulfotransferase 11 A0A024RBL0 [Target identity:100%; Query identity:100%] Carbohydrate (Chondroitin 4) sulfotransferase 11, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001537 [N-acetylgalactosamine 4-O-sulfotransferase activity] GO:0002063 [chondrocyte development] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0007585 [respiratory gaseous exchange] GO:0008146 [sulfotransferase activity] GO:0009791 [post-embryonic development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030326 [embryonic limb morphogenesis] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0033037 [polysaccharide localization] GO:0036342 [post-anal tail morphogenesis] GO:0042127 [regulation of cell proliferation] GO:0042733 [embryonic digit morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0047756 [chondroitin 4-sulfotransferase activity] GO:0048589 [developmental growth] GO:0048703 [embryonic viscerocranium morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0050659 [N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity] GO:0051216 [cartilage development] Show all	352 aa 41.6 kDa	Yes	0
CHST11-002 ENSP00000450004 ENST00000549260	Q9NPF2 [Direct mapping] Carbohydrate sulfotransferase 11 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001537 [N-acetylgalactosamine 4-O-sulfotransferase activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047756 [chondroitin 4-sulfotransferase activity] Show all	347 aa 41 kDa	No	0
CHST11-005 ENSP00000449095 ENST00000549016	F8VXK3 [Direct mapping] Carbohydrate sulfotransferase 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	158 aa 18.5 kDa	No	0
CHST11-006 ENSP00000448678 ENST00000546689	F8VRG6 [Direct mapping] Carbohydrate sulfotransferase 11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	72 aa 8.4 kDa	No	0
CHST11-007 ENSP00000449093 ENST00000547956	F8VXK7 [Direct mapping] Carbohydrate sulfotransferase 11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	77 aa 8.9 kDa	Yes	0

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