Expression of EXOSC1 in cancer - Summary - The Human Protein Atlas

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EXOSC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EXOSC1
Gene description	Exosome component 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038370
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038370

GENE INFORMATION
Gene name	EXOSC1 (HGNC Symbol)
Synonyms	CGI-108, CSL4, Csl4p, hCsl4p, p13, SKI4, Ski4p
Description	Exosome component 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	97436142 - 97446017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171311 (version 83.38)
Entrez gene	51013
UniProt	Q9Y3B2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3B2
Antibodypedia	EXOSC1 antibodies

PROTEIN BROWSER

EXOSC1-001	EXOSC1-004	EXOSC1-005	EXOSC1-008	EXOSC1-009	EXOSC1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOSC1-001 ENSP00000359939 ENST00000370902	Q9Y3B2 [Direct mapping] Exosome complex component CSL4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006364 [rRNA processing] GO:0010467 [gene expression] GO:0043488 [regulation of mRNA stability] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] Show all	195 aa 21.5 kDa	No	0
EXOSC1-004 ENSP00000359921 ENST00000370884	B1AMU7 [Direct mapping] Exosome complex component CSL4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	165 aa 17.8 kDa	No	0
EXOSC1-005 ENSP00000473303 ENST00000477692	R4GMQ7 [Direct mapping] Exosome complex component CSL4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	143 aa 15.7 kDa	No	0
EXOSC1-008 ENSP00000359922 ENST00000370885	B1AMU3 [Direct mapping] Exosome complex component CSL4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	170 aa 18.8 kDa	No	0
EXOSC1-009 ENSP00000359923 ENST00000370886	B1AMU4 [Direct mapping] Exosome complex component CSL4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	178 aa 19.5 kDa	No	0
EXOSC1-011 ENSP00000473660 ENST00000485122	R4GNH9 [Direct mapping] Exosome complex component CSL4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	139 aa 15.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.