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KRT13

GENERAL INFORMATION

Gene name

 KRT13

Gene description

 Keratin 13, type I

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, urothelial cancer)
HPA (cell line):Group enriched (A-431, HaCaT)
HPA (normal tissue):Tissue enriched (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in squamous epithelia and urothelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA030877 , CAB000133
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030877
CAB000133

GENE INFORMATION

Gene name

 KRT13 (HGNC Symbol)

Synonyms

 CK13, K13, MGC161462, MGC3781

Description

 Keratin 13, type I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41500981 - 41505705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171401 (version 83.38)

Entrez gene

 3860

UniProt

 P13646 (UniProt - Evidence at protein level)

neXtProt

 NX_P13646

Antibodypedia

 KRT13 antibodies

PROTEIN BROWSER
KRT13-001
KRT13-002
KRT13-005
KRT13-007
KRT13-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT13-001
ENSP00000246635
ENST00000246635
P13646 [Direct mapping]
Keratin, type I cytoskeletal 13
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0007010 [cytoskeleton organization]
GO:0009314 [response to radiation]
GO:0043587 [tongue morphogenesis]
GO:0045095 [keratin filament]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0071300 [cellular response to retinoic acid]
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 458 aa
49.6 kDa 		No 0
KRT13-002
ENSP00000336604
ENST00000336861
P13646 [Direct mapping]
Keratin, type I cytoskeletal 13
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0007010 [cytoskeleton organization]
GO:0045095 [keratin filament]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
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 420 aa
45.9 kDa 		No 0
KRT13-005
ENSP00000468221
ENST00000587544
K7ERE3 [Direct mapping]
Keratin, type I cytoskeletal 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045111 [intermediate filament cytoskeleton]
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 415 aa
45.3 kDa 		No 0
KRT13-007
ENSP00000466465
ENST00000590425
K7EMD9 [Direct mapping]
Keratin, type I cytoskeletal 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 165 aa
19.2 kDa 		No 0
KRT13-008
ENSP00000467833
ENST00000587435
K7EQH6 [Direct mapping]
Keratin, type I cytoskeletal 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045111 [intermediate filament cytoskeleton]
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 162 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.