Expression of XAGE3 in cancer - Summary - The Human Protein Atlas

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XAGE3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	XAGE3
Gene description	X antigen family, member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA052507 , HPA059045 , HPA060900
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA052507	HPA059045	HPA060900

GENE INFORMATION
Gene name	XAGE3 (HGNC Symbol)
Synonyms	CT12.3a, CT12.3b, GAGED4, PLAC6, pp9012, XAGE-3
Description	X antigen family, member 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	52862525 - 52868068
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171402 (version 83.38)
Entrez gene	170626
UniProt	Q8WTP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WTP9
Antibodypedia	XAGE3 antibodies

PROTEIN BROWSER

XAGE3-001	XAGE3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XAGE3-001 ENSP00000303061 ENST00000346279	Q8WTP9 [Direct mapping] X antigen family member 3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	111 aa 12.3 kDa	No	0
XAGE3-002 ENSP00000364640 ENST00000375491	Q8WTP9 [Direct mapping] X antigen family member 3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	111 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.