Expression of XAGE5 in cancer - Summary - The Human Protein Atlas

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XAGE5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	XAGE5
Gene description	X antigen family, member 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Cell line enriched (U-2 OS)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear expression in neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA052507 , HPA059045
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052507	HPA059045

GENE INFORMATION
Gene name	XAGE5 (HGNC Symbol)
Synonyms	CT12.5, GAGED5, XAGE-5
Description	X antigen family, member 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	52812204 - 52818301
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000171405 (version 83.38)
Entrez gene	170627
UniProt	Q8WWM1 (UniProt - Inferred from homology)
neXtProt	NX_Q8WWM1
Antibodypedia	XAGE5 antibodies

PROTEIN BROWSER

XAGE5-001	XAGE5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XAGE5-001 ENSP00000364651 ENST00000375501	Q8WWM1 [Direct mapping] X antigen family member 5 Show all	Predicted intracellular proteins Show all		108 aa 12.1 kDa	No	0
XAGE5-201 ENSP00000342240 ENST00000351072	Q8WWM1 [Direct mapping] X antigen family member 5 Show all	Predicted intracellular proteins Show all		108 aa 12.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.