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KSR2

GENERAL INFORMATION

Gene name

 KSR2

Gene description

 Kinase suppressor of ras 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Group enriched (HUVEC TERT2, SCLC-21H, TIME)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. GTEx data supports antibody staining in CNS.

Reliability score

 Approved based on 1 antibody.
HPA035536
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035536

GENE INFORMATION

Gene name

 KSR2 (HGNC Symbol)

Synonyms

 FLJ25965

Description

 Kinase suppressor of ras 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

Chromosome location (bp)

 117453012 - 117968983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171435 (version 83.38)

Entrez gene

 283455

UniProt

 Q6VAB6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6VAB6

Antibodypedia

 KSR2 antibodies

PROTEIN BROWSER
KSR2-001
KSR2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KSR2-001
ENSP00000339952
ENST00000339824
Q6VAB6 [Direct mapping]
Kinase suppressor of Ras 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 950 aa
107.6 kDa 		No 0
KSR2-201
ENSP00000389715
ENST00000425217
E9PB13 [Direct mapping]
Kinase suppressor of Ras 2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005078 [MAP-kinase scaffold activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0043410 [positive regulation of MAPK cascade]
GO:0046872 [metal ion binding]
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 921 aa
104.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.