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LPAR3

GENERAL INFORMATION

Gene name

 LPAR3

Gene description

 Lysophosphatidic acid receptor 3

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (fallopian tube)
GTEx:Mixed
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA013421
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 LPAR3 (HGNC Symbol)

Synonyms

 Edg-7, EDG7, HOFNH30, LP-A3, LPA3, RP4-678I3

Description

 Lysophosphatidic acid receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 84811602 - 84893213

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171517 (version 83.38)

Entrez gene

 23566

UniProt

 Q9UBY5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UBY5

Antibodypedia

 LPAR3 antibodies

PROTEIN BROWSER
LPAR3-001
LPAR3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPAR3-001
ENSP00000395389
ENST00000440886
Q9UBY5 [Direct mapping]
Lysophosphatidic acid receptor 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0000187 [activation of MAPK activity]
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0005543 [phospholipid binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [synaptic transmission]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0032060 [bleb assembly]
GO:0043410 [positive regulation of MAPK cascade]
GO:0048672 [positive regulation of collateral sprouting]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070915 [lysophosphatidic acid receptor activity]
Show all
 353 aa
40.1 kDa 		No 7
LPAR3-201
ENSP00000359643
ENST00000370611
Q9UBY5 [Direct mapping]
Lysophosphatidic acid receptor 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [synaptic transmission]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0070915 [lysophosphatidic acid receptor activity]
Show all
 353 aa
40.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.