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Cytoplasmic staining in most cancer cells, strongest staining in gliomas. Lymphomas were negative.
GENE INFORMATION
Gene name
PTGER4 (HGNC Symbol)
Synonyms
EP4
Description
Prostaglandin E receptor 4 (subtype EP4) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]