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NEUROD2

GENERAL INFORMATION

Gene name

 NEUROD2

Gene description

 Neuronal differentiation 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (cervical cancer)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NEUROD2 (HGNC Symbol)

Synonyms

 bHLHa1, NDRF

Description

 Neuronal differentiation 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39603536 - 39609777

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171532 (version 83.38)

Entrez gene

 4761

UniProt

 Q15784 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q15784

Antibodypedia

 NEUROD2 antibodies

PROTEIN BROWSER
NEUROD2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEUROD2-001
ENSP00000306754
ENST00000302584
Q15784 [Direct mapping]
Neurogenic differentiation factor 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001662 [behavioral fear response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0008306 [associative learning]
GO:0016567 [protein ubiquitination]
GO:0021695 [cerebellar cortex development]
GO:0031915 [positive regulation of synaptic plasticity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048666 [neuron development]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070888 [E-box binding]
GO:0071257 [cellular response to electrical stimulus]
GO:0071277 [cellular response to calcium ion]
GO:0090129 [positive regulation of synapse maturation]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
GO:2000297 [negative regulation of synapse maturation]
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 382 aa
41.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.