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FGG

GENERAL INFORMATION

Gene name

 FGG

Gene description

 Fibrinogen gamma chain

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA027529 , CAB033120
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027529
CAB033120

GENE INFORMATION

Gene name

 FGG

Synonyms

Description

 Fibrinogen gamma chain (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 154604134 - 154612967

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171557 (version 83.38)

Entrez gene

 2266

UniProt

 P02679 (UniProt - Evidence at protein level)

neXtProt

 NX_P02679

Antibodypedia

 FGG antibodies

PROTEIN BROWSER
FGG-001
FGG-002
FGG-006
FGG-007
FGG-008
FGG-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGG-001
ENSP00000384860
ENST00000404648
P02679 [Direct mapping]
Fibrinogen gamma chain
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009306 [protein secretion]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043623 [cellular protein complex assembly]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
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 437 aa
49.5 kDa 		Yes 0
FGG-002
ENSP00000336829
ENST00000336098
P02679 [Direct mapping]
Fibrinogen gamma chain
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009306 [protein secretion]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043623 [cellular protein complex assembly]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 453 aa
51.5 kDa 		Yes 0
FGG-006
ENSP00000384101
ENST00000405164
C9JEU5 [Direct mapping]
Fibrinogen gamma chain
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005577 [fibrinogen complex]
GO:0007165 [signal transduction]
GO:0030168 [platelet activation]
GO:0030674 [protein binding, bridging]
GO:0051258 [protein polymerization]
Show all
 445 aa
50.3 kDa 		Yes 0
FGG-007
ENSP00000384552
ENST00000407946
C9JC84 [Direct mapping]
Fibrinogen gamma chain
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005577 [fibrinogen complex]
GO:0007165 [signal transduction]
GO:0030168 [platelet activation]
GO:0030674 [protein binding, bridging]
GO:0051258 [protein polymerization]
Show all
 461 aa
52.3 kDa 		Yes 0
FGG-008
ENSP00000407562
ENST00000443553
C9JU00 [Direct mapping]
Fibrinogen gamma chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005577 [fibrinogen complex]
GO:0007165 [signal transduction]
GO:0030168 [platelet activation]
GO:0030674 [protein binding, bridging]
GO:0051258 [protein polymerization]
Show all
 123 aa
14 kDa 		No 0
FGG-009
ENSP00000377429
ENST00000393846
C9JPQ9 [Direct mapping]
Fibrinogen gamma chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005577 [fibrinogen complex]
GO:0007165 [signal transduction]
GO:0030168 [platelet activation]
GO:0030674 [protein binding, bridging]
GO:0051258 [protein polymerization]
Show all
 119 aa
13.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.