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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FGB
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FGB

Gene description

Fibrinogen beta chain

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in hepatocytes, and strong positivity in plasma and extracellular compartments.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA001900 , HPA001901 , CAB008624
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001900
HPA001901
CAB008624

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies showed weak to moderate cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Distinct staining was observed in tumor stroma. A few colorectal-, liver-, urothelial- and pancreatic cancers displayed weak cytoplasmic immunoreactivity. Remaining malignant cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Stromal cells and extra cellular material were distinctly stained in most malignancies. Moderate to strong cytoplasmic and/or membranous staining was observed in a fraction of cells in most cases of hepatocellular carcinomas, urothelia, renal, breast and ovarian cancers along with a few cases of most other malignancies. Most malignant cells were however in general weakly stained or negative.

GENE INFORMATION

Gene name

FGB

Synonyms

Description

Fibrinogen beta chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

154562956 - 154571086

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171564 (version 83.38)

Entrez gene

2244

UniProt

P02675 (UniProt - Evidence at protein level)

neXtProt

NX_P02675

Antibodypedia

FGB antibodies

PROTEIN BROWSER

FGB-001
FGB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGB-001
ENSP00000306099
ENST00000302068
P02675 [Direct mapping]
Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain
V9HVY1 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 78p
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response]
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043152 [induction of bacterial agglutination]
GO:0043623 [cellular protein complex assembly]
GO:0044320 [cellular response to leptin stimulus]
GO:0045087 [innate immune response]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071347 [cellular response to interleukin-1]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903561 [extracellular vesicle]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
491 aa
55.9 kDa
Yes 0
FGB-010
ENSP00000426757
ENST00000509493
D6REL8 [Direct mapping]
Fibrinogen beta chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
272 aa
31.2 kDa
No 0

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