Fields »
ABOUT
HELP
BLOG
PLRG1

GENERAL INFORMATION

Gene name

 PLRG1

Gene description

 Pleiotropic regulator 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035931 , HPA035932
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035931
HPA035932

GENE INFORMATION

Gene name

 PLRG1 (HGNC Symbol)

Synonyms

 Cwc1, PRL1, Prp46, PRPF46, TANGO4

Description

 Pleiotropic regulator 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 4

Cytoband

 q31.3

Chromosome location (bp)

 154535006 - 154550435

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171566 (version 83.38)

Entrez gene

 5356

UniProt

 O43660 (UniProt - Evidence at protein level)

neXtProt

 NX_O43660

Antibodypedia

 PLRG1 antibodies

PROTEIN BROWSER
PLRG1-001
PLRG1-003
PLRG1-006
PLRG1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLRG1-001
ENSP00000424417
ENST00000499023
O43660 [Direct mapping]
Pleiotropic regulator 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0034504 [protein localization to nucleus]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0080008 [Cul4-RING E3 ubiquitin ligase complex]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
Show all
 514 aa
57.2 kDa 		No 0
PLRG1-003
ENSP00000303191
ENST00000302078
O43660 [Direct mapping]
Pleiotropic regulator 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0080008 [Cul4-RING E3 ubiquitin ligase complex]
Show all
 505 aa
56.3 kDa 		No 0
PLRG1-006
ENSP00000423454
ENST00000504341
D6RA26 [Direct mapping]
Pleiotropic regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 212 aa
23.5 kDa 		No 0
PLRG1-012
ENSP00000426497
ENST00000503251
H0YAA2 [Direct mapping]
Pleiotropic regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 106 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.