Expression of CXXC5 in cancer - Summary - The Human Protein Atlas

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CXXC5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CXXC5
Gene description	CXXC finger protein 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036508
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and colorectal cancer (favourable).
Endometrial cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036508

GENE INFORMATION
Gene name	CXXC5 (HGNC Symbol)
Synonyms	HSPC195, RINF, WID
Description	CXXC finger protein 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	5
Cytoband	q31.2
Chromosome location (bp)	139647299 - 139683882
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171604 (version 83.38)
Entrez gene	51523
UniProt	Q7LFL8 (UniProt - Evidence at protein level)
neXtProt	NX_Q7LFL8
Antibodypedia	CXXC5 antibodies

PROTEIN BROWSER

CXXC5-001	CXXC5-002	CXXC5-005	CXXC5-006	CXXC5-007	CXXC5-008	CXXC5-009	CXXC5-010	CXXC5-011	CXXC5-013	CXXC5-014	CXXC5-016	CXXC5-017	CXXC5-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXXC5-001 ENSP00000302543 ENST00000302517	Q7LFL8 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007165 [signal transduction] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043565 [sequence-specific DNA binding] Show all	322 aa 33 kDa	No	0
CXXC5-002 ENSP00000427379 ENST00000511048	Q7LFL8 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007165 [signal transduction] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043565 [sequence-specific DNA binding] Show all	322 aa 33 kDa	No	0
CXXC5-005 ENSP00000427127 ENST00000502295	D6RCN9 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 6.3 kDa	No	0
CXXC5-006 ENSP00000422883 ENST00000504944	D6R9V1 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 9.6 kDa	No	0
CXXC5-007 ENSP00000423365 ENST00000512816	D6R966 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 6.8 kDa	No	0
CXXC5-008 ENSP00000427440 ENST00000509238	D6RIR8 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 9.2 kDa	No	0
CXXC5-009 ENSP00000427253 ENST00000507139	D6RJC1 [Direct mapping] CXXC-type zinc finger protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		11 aa 1 kDa	No	0
CXXC5-010 ENSP00000425203 ENST00000504844	D6RDY2 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 15.3 kDa	No	0
CXXC5-011 ENSP00000426124 ENST00000502336	D6RHG9 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 7.6 kDa	No	0
CXXC5-013 ENSP00000421866 ENST00000511591		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.7 kDa	No	0
CXXC5-014 ENSP00000424219 ENST00000502716	D6RBE0 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	181 aa 17.7 kDa	No	0
CXXC5-016 ENSP00000421057 ENST00000503511	D6RHC6 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		83 aa 8 kDa	No	0
CXXC5-017 ENSP00000430949 ENST00000511457	E7EVI8 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	197 aa 19.3 kDa	No	0
CXXC5-018 ENSP00000430522 ENST00000520967	E7EV55 [Direct mapping] CXXC-type zinc finger protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 13 kDa	No	0

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