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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SLC25A33
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SLC25A33

Gene description

Solute carrier family 25 (pyrimidine nucleotide carrier), member 33

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA049982
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PROGNOSTIC SUMMARY

Prognostic marker in cervical cancer (favourable) and lung cancer (favourable).
Cervical cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA049982

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic and/or nuclear immunoreactivity was observed in melanomas, colorectal, breast, testicular and a few cervical cancers. Remaining cancer tissues were generally negative.

GENE INFORMATION

Gene name

SLC25A33 (HGNC Symbol)

Synonyms

BMSC-MCP, MGC4399, PNC1

Description

Solute carrier family 25 (pyrimidine nucleotide carrier), member 33 (HGNC Symbol)

Entrez gene summary

SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

9539482 - 9585179

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171612 (version 83.38)

Entrez gene

84275

UniProt

Q9BSK2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BSK2

Antibodypedia

SLC25A33 antibodies

PROTEIN BROWSER

SLC25A33-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC25A33-001
ENSP00000306328
ENST00000302692
Q9BSK2 [Direct mapping]
Solute carrier family 25 member 33
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000002 [mitochondrial genome maintenance]
GO:0002082 [regulation of oxidative phosphorylation]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006264 [mitochondrial DNA replication]
GO:0006390 [transcription from mitochondrial promoter]
GO:0006864 [pyrimidine nucleotide transport]
GO:0007005 [mitochondrion organization]
GO:0008284 [positive regulation of cell proliferation]
GO:0015218 [pyrimidine nucleotide transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0030307 [positive regulation of cell growth]
GO:0031930 [mitochondria-nucleus signaling pathway]
GO:0031966 [mitochondrial membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0034551 [mitochondrial respiratory chain complex III assembly]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0071156 [regulation of cell cycle arrest]
GO:1903426 [regulation of reactive oxygen species biosynthetic process]
GO:1990314 [cellular response to insulin-like growth factor stimulus]
GO:1990519 [mitochondrial pyrimidine nucleotide import]
Show all
321 aa
35.4 kDa
No 1

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