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PLEKHG5

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GENERAL INFORMATION

Gene name

 PLEKHG5

Gene description

 Pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA049570
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049570 SH-SY5Y No staining    
HPA049570 U-2 OS Nucleus

GENE INFORMATION

Gene name

 PLEKHG5 (HGNC Symbol)

Synonyms

 GEF720, KIAA0720, Syx, Tech

Description

 Pleckstrin homology domain containing, family G (with RhoGef domain) member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 1

Cytoband

 p36.31

Chromosome location (bp)

 6466092 - 6520061

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171680 (version 83.38)

Entrez gene

 57449

UniProt

 O94827 (UniProt - Evidence at protein level)

neXtProt

 NX_O94827

Antibodypedia

 PLEKHG5 antibodies

PROTEIN BROWSER
PLEKHG5-001
PLEKHG5-002
PLEKHG5-003
PLEKHG5-004
PLEKHG5-005
PLEKHG5-006
PLEKHG5-201
PLEKHG5-202
PLEKHG5-203
PLEKHG5-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLEKHG5-001
ENSP00000366977
ENST00000377748
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1083 aa
119.7 kDa 		No 0
PLEKHG5-002
ENSP00000383706
ENST00000400915
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1062 aa
117.5 kDa 		No 0
PLEKHG5-003
ENSP00000366969
ENST00000377740
Q5SY18 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 852 aa
96.3 kDa 		No 0
PLEKHG5-004
ENSP00000366961
ENST00000377732
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1043 aa
115.4 kDa 		No 0
PLEKHG5-005
ENSP00000366957
ENST00000377728
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1006 aa
111.2 kDa 		No 0
PLEKHG5-006
ENSP00000366954
ENST00000377725
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 930 aa
103.4 kDa 		No 0
PLEKHG5-201
ENSP00000344570
ENST00000340850
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1006 aa
111.2 kDa 		No 0
PLEKHG5-202
ENSP00000383704
ENST00000400913
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1006 aa
111.2 kDa 		No 0
PLEKHG5-203
ENSP00000441445
ENST00000535355
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1075 aa
118.5 kDa 		No 0
PLEKHG5-204
ENSP00000439625
ENST00000537245
O94827 [Direct mapping]
Pleckstrin homology domain-containing family G member 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035767 [endothelial cell chemotaxis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043542 [endothelial cell migration]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1085 aa
119.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.