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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001934 [positive regulation of protein phosphorylation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005886 [plasma membrane] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007219 [Notch signaling pathway] GO:0007346 [regulation of mitotic cell cycle] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0017053 [transcriptional repressor complex] GO:0019899 [enzyme binding] GO:0030332 [cyclin binding] GO:0031490 [chromatin DNA binding] GO:0031647 [regulation of protein stability] GO:0032008 [positive regulation of TOR signaling] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0032922 [circadian regulation of gene expression] GO:0033558 [protein deacetylase activity] GO:0040014 [regulation of multicellular organism growth] GO:0042826 [histone deacetylase binding] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051225 [spindle assembly] GO:0070932 [histone H3 deacetylation] GO:0071498 [cellular response to fluid shear stress] GO:1903507 [negative regulation of nucleic acid-templated transcription] GO:2000726 [negative regulation of cardiac muscle cell differentiation]