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Several cases of melanoma, lung, testis and liver with rare cases of colorectal, ovarian, thyroid and skin cancers showed moderate nuclear staining. Few cases of urothelial cancers showed moderate cytoplasmic and nuclear staining. Remaining cancer tissues were weakly stained or negative.
Most cancer tissues were weakly stained or negative. Several melanomas as well as a few endometrial, prostate, colorectal and hepatocellular carcinomas showed moderate cytoplasmic and nuclear positivity.
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014)
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GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050885 [neuromuscular process controlling balance]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]