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RASGRP4

GENERAL INFORMATION

Gene name

 RASGRP4

Gene description

 RAS guanyl releasing protein 4

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Group enriched (HEL, HMC-1, U-937)
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RASGRP4

Synonyms

Description

 RAS guanyl releasing protein 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38409051 - 38426305

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171777 (version 83.38)

Entrez gene

 115727

UniProt

 Q8TDF6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDF6

Antibodypedia

 RASGRP4 antibodies

PROTEIN BROWSER
«
RASGRP4-003
RASGRP4-004
RASGRP4-005
RASGRP4-006
RASGRP4-009
RASGRP4-012
RASGRP4-013
RASGRP4-201
RASGRP4-202
RASGRP4-203
RASGRP4-204
RASGRP4-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASGRP4-003
ENSP00000479888
ENST00000617966
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 576 aa
64.3 kDa 		No 0
RASGRP4-004
ENSP00000484345
ENST00000622174
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 484 aa
53.9 kDa 		No 0
RASGRP4-005
ENSP00000416463
ENST00000454404
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 639 aa
71.3 kDa 		No 0
RASGRP4-006
ENSP00000468483
ENST00000587753
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 604 aa
67 kDa 		No 0
RASGRP4-009
ENSP00000479078
ENST00000614135
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 581 aa
64.5 kDa 		No 0
RASGRP4-012
ENSP00000467604
ENST00000586305
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 659 aa
73.6 kDa 		No 0
RASGRP4-013
ENSP00000465772
ENST00000587738
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 673 aa
74.9 kDa 		No 0
RASGRP4-201
ENSP00000293062
ENST00000293062
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 576 aa
64.3 kDa 		No 0
RASGRP4-202
ENSP00000445966
ENST00000426920
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 484 aa
53.9 kDa 		No 0
RASGRP4-203
ENSP00000411878
ENST00000433821
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 581 aa
64.5 kDa 		No 0
RASGRP4-204
ENSP00000479844
ENST00000615439
Q8TDF6 [Direct mapping]
RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0019992 [diacylglycerol binding]
GO:0030099 [myeloid cell differentiation]
GO:0030742 [GTP-dependent protein binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 673 aa
74.9 kDa 		No 0
RASGRP4-205
ENSP00000481053
ENST00000618320
C0LTP6 [Direct mapping]
RAS guanyl releasing protein 4 variant 9; RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 617 aa
68.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.