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NHLH1

GENERAL INFORMATION

Gene name

 NHLH1

Gene description

 Nescient helix loop helix 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, testis cancer, urothelial cancer)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Not detected

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB033854
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, testis cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB033854

GENE INFORMATION

Gene name

 NHLH1 (HGNC Symbol)

Synonyms

 bHLHa35, HEN1, NSCL, NSCL1

Description

 Nescient helix loop helix 1 (HGNC Symbol)

Entrez gene summary

 The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 160367067 - 160372848

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000171786 (version 83.38)

Entrez gene

 4807

UniProt

 Q02575 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q02575

Antibodypedia

 NHLH1 antibodies

PROTEIN BROWSER
NHLH1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NHLH1-001
ENSP00000302189
ENST00000302101
Q02575 [Direct mapping]
Helix-loop-helix protein 1
Q5T203 [Target identity:100%; Query identity:100%]
Nescient helix loop helix 1; cDNA, FLJ94293, Homo sapiens nescient helix loop helix 1 (NHLH1), mRNA
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0030154 [cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
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 133 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.