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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BCL2
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BCL2

Gene description

B-cell CLL/lymphoma 2

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707, U-266/70)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including thyroid gland and lymphoid organs.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB000003
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable), cervical cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Thyroid cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

CAB000003

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic staining in several lymphomas, melanomas, lung, breast, endometrial, skin, renal and pancreatic cancers. Most other cancers tissues were negative. Subsets of immune cells showed strong cytoplasmic staining.

GENE INFORMATION

Gene name

BCL2 (HGNC Symbol)

Synonyms

Bcl-2, PPP1R50

Description

B-cell CLL/lymphoma 2 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q21.33

Chromosome location (bp)

63123346 - 63320128

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171791 (version 83.38)

Entrez gene

596

UniProt

P10415 (UniProt - Evidence at protein level)

neXtProt

NX_P10415

Antibodypedia

BCL2 antibodies

PROTEIN BROWSER

BCL2-001
BCL2-002
BCL2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2-001
ENSP00000381185
ENST00000398117
P10415 [Direct mapping]
Apoptosis regulator Bcl-2
A0A024R2B3 [Target identity:100%; Query identity:100%]
B-cell CLL/lymphoma 2, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000902 [cell morphogenesis]
GO:0001503 [ossification]
GO:0001541 [ovarian follicle development]
GO:0001656 [metanephros development]
GO:0001657 [ureteric bud development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001662 [behavioral fear response]
GO:0001776 [leukocyte homeostasis]
GO:0001782 [B cell homeostasis]
GO:0001822 [kidney development]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0002020 [protease binding]
GO:0002260 [lymphocyte homeostasis]
GO:0002320 [lymphoid progenitor cell differentiation]
GO:0002326 [B cell lineage commitment]
GO:0002360 [T cell lineage commitment]
GO:0002520 [immune system development]
GO:0002931 [response to ischemia]
GO:0003014 [renal system process]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006582 [melanin metabolic process]
GO:0006808 [regulation of nitrogen utilization]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007015 [actin filament organization]
GO:0007409 [axonogenesis]
GO:0007565 [female pregnancy]
GO:0007569 [cell aging]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009314 [response to radiation]
GO:0009636 [response to toxic substance]
GO:0009791 [post-embryonic development]
GO:0009887 [organ morphogenesis]
GO:0010039 [response to iron ion]
GO:0010224 [response to UV-B]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0010506 [regulation of autophagy]
GO:0010507 [negative regulation of autophagy]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0010559 [regulation of glycoprotein biosynthetic process]
GO:0012501 [programmed cell death]
GO:0014031 [mesenchymal cell development]
GO:0014042 [positive regulation of neuron maturation]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016248 [channel inhibitor activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0021747 [cochlear nucleus development]
GO:0022612 [gland morphogenesis]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030097 [hemopoiesis]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0030318 [melanocyte differentiation]
GO:0030336 [negative regulation of cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031069 [hair follicle morphogenesis]
GO:0031103 [axon regeneration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031965 [nuclear membrane]
GO:0031966 [mitochondrial membrane]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032835 [glomerulus development]
GO:0032848 [negative regulation of cellular pH reduction]
GO:0032880 [regulation of protein localization]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0033077 [T cell differentiation in thymus]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0034097 [response to cytokine]
GO:0035094 [response to nicotine]
GO:0035265 [organ growth]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040007 [growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042100 [B cell proliferation]
GO:0042149 [cellular response to glucose starvation]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043029 [T cell homeostasis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043067 [regulation of programmed cell death]
GO:0043085 [positive regulation of catalytic activity]
GO:0043209 [myelin sheath]
GO:0043375 [CD8-positive, alpha-beta T cell lineage commitment]
GO:0043473 [pigmentation]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043583 [ear development]
GO:0045069 [regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045636 [positive regulation of melanocyte differentiation]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046671 [negative regulation of retinal cell programmed cell death]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0048041 [focal adhesion assembly]
GO:0048066 [developmental pigmentation]
GO:0048070 [regulation of developmental pigmentation]
GO:0048087 [positive regulation of developmental pigmentation]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048545 [response to steroid hormone]
GO:0048546 [digestive tract morphogenesis]
GO:0048589 [developmental growth]
GO:0048599 [oocyte development]
GO:0048743 [positive regulation of skeletal muscle fiber development]
GO:0048753 [pigment granule organization]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050790 [regulation of catalytic activity]
GO:0050853 [B cell receptor signaling pathway]
GO:0051384 [response to glucocorticoid]
GO:0051402 [neuron apoptotic process]
GO:0051434 [BH3 domain binding]
GO:0051607 [defense response to virus]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051924 [regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071310 [cellular response to organic substance]
GO:0071456 [cellular response to hypoxia]
GO:0072593 [reactive oxygen species metabolic process]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000811 [negative regulation of anoikis]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
239 aa
26.3 kDa
No 2
BCL2-002
ENSP00000329623
ENST00000333681
P10415 [Direct mapping]
Apoptosis regulator Bcl-2
A0A024R2B3 [Target identity:100%; Query identity:100%]
B-cell CLL/lymphoma 2, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007565 [female pregnancy]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009314 [response to radiation]
GO:0009636 [response to toxic substance]
GO:0010039 [response to iron ion]
GO:0010507 [negative regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016248 [channel inhibitor activity]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030307 [positive regulation of cell growth]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031965 [nuclear membrane]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032848 [negative regulation of cellular pH reduction]
GO:0034097 [response to cytokine]
GO:0035094 [response to nicotine]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042100 [B cell proliferation]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0050853 [B cell receptor signaling pathway]
GO:0051402 [neuron apoptotic process]
GO:0051434 [BH3 domain binding]
GO:0051607 [defense response to virus]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051924 [regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000811 [negative regulation of anoikis]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
239 aa
26.3 kDa
No 2
BCL2-003
ENSP00000466417
ENST00000589955
P10415 [Direct mapping]
Apoptosis regulator Bcl-2
A0A024R2C4 [Target identity:100%; Query identity:100%]
B-cell CLL/lymphoma 2, isoform CRA_b
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007565 [female pregnancy]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009314 [response to radiation]
GO:0009636 [response to toxic substance]
GO:0010039 [response to iron ion]
GO:0010507 [negative regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016248 [channel inhibitor activity]
GO:0022898 [regulation of transmembrane transporter activity]
GO:0030307 [positive regulation of cell growth]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031965 [nuclear membrane]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032848 [negative regulation of cellular pH reduction]
GO:0034097 [response to cytokine]
GO:0035094 [response to nicotine]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042100 [B cell proliferation]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0050853 [B cell receptor signaling pathway]
GO:0051402 [neuron apoptotic process]
GO:0051434 [BH3 domain binding]
GO:0051607 [defense response to virus]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051924 [regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000811 [negative regulation of anoikis]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
205 aa
22.3 kDa
No 0

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  • ORGANIZATION
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The Human Protein Atlas

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The Human Protein Atlas project is funded
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